Today’s historical research agenda shows a renewed interest in the link between the emergence of the Reformation and the transformation of written communication systems. Even if the power of the phenomenon of mediatisation came as a surprise to the Reformers, they soon managed to develop a practice that made their communication more effective for a wider readership. But also their opposite camp, constituted by the followers of Rome, very early on had specialists of “Publizistik”, among whom the Strasbourg Franciscan Thomas Murner was certainly the most brilliant. The article gives an overview of the publication of some of Murner’s most important works, in particular the Von dem großen Lutherischen Narren of 1522, and discusses the main strategies that he employed to make his message more effective.