This article studies the evolution of Lyon’s printed production in the 15^th century during. While the initiator of printing in Lyon, Barthélemy Buyer, had chosen to produce in French for a lay readership, this production quickly ran out of steam while keeping its initial characteristics. At the same time, law and literature for the clergy, developed in different ways, occupied an important place in Lyon’s production. At the end of the 1480s when printers invested massively in in-quarto books, which were less expensive and quicker to produce, this production developed rapidly before a first major crisis which reinforced the previous trends.